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Free NABP NAPLEX Practice Exam with Questions & Answers

Questions 1

An 18-year-old female is referred to a dermatologist for treatment of severe acne vulgaris. The dermatologist wants to start her on tetracycline.

What test should the patient have prior to starting treatment?

Options:
A.

Pregnancy test

B.

Chest X-ray

C.

Complete blood count

D.

Liver function tests

E.

Creatine kinase

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Questions 2

Results from a Meta-analysis where they looked at frequency of postoperative arterial fibrillation in patients on Ascorbic acid after cardiac surgery found odds ratio, 0.44 (95% CI, 0.32 to 0.61). How can you interpret this data?

Options:
A.

Ascorbic acid increased frequency of postoperative arterial fibrillation after cardiac surgery by 44%

B.

Ascorbic acid decreased frequency of postoperative arterial fibrillation after cardiac surgery by 44%

C.

There was no statistically significant difference in frequency of postoperative arterial fibrillation after cardiac surgery

D.

Ascorbic acid decreased frequency of postoperative arterial fibrillation after cardiac surgery by 56%

E.

None of the above are correct

Questions 3

Which of these ranges reflects normal serum creatinine levels?

Options:
A.

0.2 - 0.5 mg/dL

B.

0.6 - 1.2 mg/dL

C.

1.5 - 2.0 mg/dL

D.

2.4 - 3.2 mg/dL

E.

3.5 - 5.0 mg/dL

Questions 4

JM is a 32-year-old women who comes to your diabetic clinic with complain of several episodes of hypoglycemia. She is on Insulin NPH/regular 70/30, 22 units twice a day with breakfast and dinner. 8 units with lunch.

After discussing with physician you decide to decrease the total daily insulin by 10% and change to insulin glargine once a day and Insulin Lispro three time a day at ratio of 50:50 – 50 % of long and 50 % of short acting insulin.

What is her new insulin regimen? Round down to the nearest 1 unit.

Options:
A.

16 units of insulin glargine once daily, Insulin Lispro 4 units 3 times a day with meals

B.

15 units of insulin glargine once daily, Insulin Lispro 5 units 3 times a day with meals

C.

23 units of insulin glargine once daily, Insulin Lispro 7 units 3 times a day with meals

D.

30 units of insulin glargine once daily, Insulin Lispro 6 units 3 times a day with meals

E.

18 units of insulin glargine once daily, Insulin Lispro 6 units 3 times a day with meals

Questions 5

In the US Nurses’ Health Study (NHS) cohort study, where they looked at association of regular aspirin use (≥two 325 mg tablets/week) and colorectal cancer in 82,911 women found (RR, 0.77; 95% CI, 0.67–0.88) over 20 years of follow-up.

In an another analysis of the NHS, regular aspirin use, investigator also found (hazard ratio [HR]=0.72, 95% CI 0.56–0.92), what does this say about the mortality from colorectal cancer? How can this data best be interpreted?

Options:
A.

Those who takes aspirin ≥2 times/week have 23% lower risk of colorectal cancer

B.

Those who takes aspirin ≥2 times/week have 0.77% lower risk of colorectal cancer

C.

Those who takes aspirin ≥2 times/week have 28% lower risk of colorectal cancer

D.

Those who takes aspirin ≥2 times/week have 23% reduction in death from colorectal cancer

E.

None of the above is correct

Questions 6

Which of the following is dichotomous variable?

Options:
A.

Sex

B.

Pain yes/ Pain no

C.

alive / dead

D.

Grade of Breast Cancer

E.

NYHA I-IV

Questions 7

What vitamin should the a patient receive to avoid Wernicke- Korsakoff syndrome?

Options:
A.

Thiamine

B.

Cyanocobalamin

C.

Folic Acid

D.

Nicotinic Acid

E.

Magnesium

Questions 8

LN is 84 YOM who is in hospital for a back surgery. His height is 5 feet and 4 inches, weight 85 kg and NKDA.

His past medical history includes hypertension, diabetes mellitus, major depression, hypothyroidism and chronic back pain. Post-op day 1, LN’s medication includes Dexamethasone 8mg iv q6h with taper dosing, Ondansetron 4mg iv q6h prn for N/V, Levothyroxine 0.075mg po daily, Lisinopril 10mg po daily, Citalopram 20mg po daily, Docusate sodium / Senna 1 tab po twice a day, Bisacodyl 10mg suppository daily prn for constipation, Famotidine 20 mg iv q12hr, Metoclopramide 10mg iv q6h, Metformin 500mg po bid, D51/2NS

with 20K at 125 mls/hour and Hydromorphone PCA at 0.2 mg/hour of basal rate, demand dose 0.1mg. lock-out every 6min, one hour limit 2.2mg/hour. Pertinent morning labs includes serum creatinine 1.4mg/dl, Mg 1.5mg/ dl, K 5.0mmol/L, Na 135mmol/L. Day 3 post-operation LN’s pain was much better and only used 3 mg of hydromorphone in the 24hrs.

Physician wants to change to oral morphine. What would be your best recommendation?

Options:
A.

Morphine SR 10mg po daily and morphine 5mg po q6h prn for breakthrough pain

B.

Morphine 60mg ER po daily and morphine 15mg po q6h prn breakthrough pain

C.

Morphine 30mg ER po q6hr and morphine 5mg q6h prn for breakthrough pain

D.

Morphine 15mg ER po q12hr and morphine 15mg po q6h prn for breakthrough pain

E.

Morphine 15mg ER po q12hr and morphine 5mg po q6h prn breakthrough pain

Questions 9

A Physician orders Dobutamine HCl IV infusion at 5 mcg/kg/min. Dobutamine HCl is available as 500 mg in 250 mL of D5W. The patient weighs 68 kg. Calculate the infusion rate in mL/hr.

Options:
A.

10.2mls/hr

B.

5.2mls/hr

C.

0.17mls/hr

D.

22.4mls/hr

E.

340mls/hr

Questions 10

Alteplase is ordered for a 72 YOM who weighs 68kg for Ischemic stroke. The ER physician would like you to dose. As an ER pharmacist you know the dose is 0.9 mg/kg IV (not to exceed 90 mg); give 10% of the total dose as an IV bolus over 1 minute, then give the remaining 90% as an IV infusion over 60 minutes. After reconstitution, the concentration of Altaplace is 1mg/ml. How many ml is needed for the bolus and how many ml is needed for the infusion? Round to the nearest ml.

Options:
A.

6ml IV bolus, followed by 55mL IV over 60 minutes

B.

4ml IV bolus, followed by 57mL IV over 60 minutes

C.

3ml IV bolus, followed by 58mL IV over 60 minutes

D.

8ml IV bolus, followed by 52mL IV over 60 minutes

E.

9ml IV bolus, followed by 82mL IV over 60 minutes

Exam Code: NAPLEX
Certification Provider: NABP
Exam Name: North American Pharmacist Licensure Examination
Last Update: Jul 17, 2025
Questions: 154

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